Structure of PDB 2hzp Chain A

Receptor sequence
>2hzpA (length=447) Species: 9606 (Homo sapiens) [Search protein sequence]
LELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLP
PVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVG
KRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKR
YKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDIL
EVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAV
GNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGW
FGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMK
ALRKKSVLLTGYLEYLIKHNYGKVVNIITPSHVEERGCQLTITFSVPNKD
VFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDS
3D structure
PDB2hzp Crystal Structure of Homo sapiens Kynureninase.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F165 D250 Y275 K276 R434
Catalytic site (residue number reindexed from 1) F160 D245 Y270 K271 R421
Enzyme Commision number 3.7.1.3: kynureninase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 PLP A L137 T138 F165 D168 D250 A252 H253 Y275 K276 L132 T133 F160 D163 D245 A247 H248 Y270 K271
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0030170 pyridoxal phosphate binding
GO:0030429 kynureninase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006569 tryptophan catabolic process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0019805 quinolinate biosynthetic process
GO:0034341 response to type II interferon
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0034516 response to vitamin B6
GO:0043420 anthranilate metabolic process
GO:0097053 L-kynurenine catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:2hzp, PDBe:2hzp, PDBj:2hzp
PDBsum2hzp
PubMed17300176
UniProtQ16719|KYNU_HUMAN Kynureninase (Gene Name=KYNU)

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