Structure of PDB 2hz4 Chain A

Receptor sequence
>2hz4A (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
KWEMERTDITMKHKLGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAV
VLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM
TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMS
PYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAE
IHQAFETMFQES
3D structure
PDB2hz4 Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1) D125 A127 R129 N130 D143 P164
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4ST A W261 Y264 L266 K294 L302 W23 Y26 L28 K56 L64 PDBbind-CN: -logKd/Ki=5.47,IC50=3425nM
BS02 4ST A Y342 F497 Q498 S500 Y104 F259 Q260 S262 PDBbind-CN: -logKd/Ki=5.47,IC50=3425nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2hz4, PDBe:2hz4, PDBj:2hz4
PDBsum2hz4
PubMed17164530
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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