Structure of PDB 2hyp Chain A

Receptor sequence
>2hypA (length=230) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PRPDYVLLHISDTHLIGGDDADDRLGELLEQLNQSGLRPDAIVFTGDLAA
KGEPAAYRKLRGLVEPFAAQLGAELVWVMGNHDDRAELRKFLLDEAPSMA
PLDRVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPAPDGTIL
ALHHPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATF
VGIPVSVASATCGCNLVHVYPDTVVHSVIP
3D structure
PDB2hyp Structural and Biochemical Analysis of the Rv0805 Cyclic Nucleotide Phosphodiesterase from Mycobacterium tuberculosis.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.16: 2',3'-cyclic-nucleotide 2'-phosphodiesterase.
3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A D21 H23 D63 H209 D12 H14 D47 H193
BS02 MN A D63 N97 H169 H207 D47 N81 H153 H191
BS03 CAC A H23 D63 N97 H98 H207 H209 H14 D47 N81 H82 H191 H193
Gene Ontology
Molecular Function
GO:0004112 cyclic-nucleotide phosphodiesterase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:2hyp, PDBe:2hyp, PDBj:2hyp
PDBsum2hyp
PubMed17059828
UniProtP9WP65|CNPD3_MYCTU cAMP/cGMP dual specificity phosphodiesterase Rv0805 (Gene Name=Rv0805)

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