Structure of PDB 2hyo Chain A

Receptor sequence
>2hyoA (length=227) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PRPDYVLLHISDTHLIDADDRLGELLEQLNQSGLRPDAIVFTGDLADKGE
PAAYRKLRGLVEPFAAQLGAELVWVMGAHDDRAELRKFLLDEAPSMAPLD
RVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPAPDGTILALH
HPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATFVGI
PVSVASATCGCNLVHVYPDTVVHSVIP
3D structure
PDB2hyo Structural and Biochemical Analysis of the Rv0805 Cyclic Nucleotide Phosphodiesterase from Mycobacterium tuberculosis.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.16: 2',3'-cyclic-nucleotide 2'-phosphodiesterase.
3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A D21 H23 D63 H209 D12 H14 D44 H190
BS02 MN A D63 H169 H207 D44 H150 H188
Gene Ontology
Molecular Function
GO:0004112 cyclic-nucleotide phosphodiesterase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:2hyo, PDBe:2hyo, PDBj:2hyo
PDBsum2hyo
PubMed17059828
UniProtP9WP65|CNPD3_MYCTU cAMP/cGMP dual specificity phosphodiesterase Rv0805 (Gene Name=Rv0805)

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