Structure of PDB 2hwr Chain A

Receptor sequence
>2hwrA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT
LLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP
KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA
LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLH
PLLQEIYKDLY
3D structure
PDB2hwr Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists
ChainA
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DRD A E259 R280 F282 G284 C285 Q286 R288 S289 H323 L330 I341 F363 M364 H449 Y473 E53 R64 F66 G68 C69 Q70 R72 S73 H107 L114 I125 F147 M148 H233 Y257 BindingDB: EC50=210nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hwr, PDBe:2hwr, PDBj:2hwr
PDBsum2hwr
PubMed17034149
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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