Structure of PDB 2hwp Chain A

Receptor sequence
>2hwpA (length=245) Species: 9031 (Gallus gallus) [Search protein sequence]
AKDAWEIPRESLRVKLGQGCGEVWMGTWNGTTRVAIKTFLQAQVMKKLRH
EKLVQLYAVVSEPIYIVTEYMSKGCLLDFLKGEMGKYLRLPQLVDMAAQI
ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFFPIKWTAPEAALYGR
FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP
ESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
3D structure
PDB2hwp Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
ChainA
Resolution2.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D116 R118 A120 N121 D134 F136
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DJK A A293 K295 I336 C345 L393 D404 A35 K37 I66 C75 L123 D134 PDBbind-CN: -logKd/Ki=7.14,IC50=0.073uM
BindingDB: IC50=>27000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2hwp, PDBe:2hwp, PDBj:2hwp
PDBsum2hwp
PubMed17334377
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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