Structure of PDB 2hw2 Chain A

Receptor sequence
>2hw2A (length=138) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
PKPFEVHESGAYLHGTKAELKVGDRLVPGRESNFEAGRIMNHIYITQTLD
AAVWGAELAAGEGRGRIFIVEPEGAIEDDPNVTDKKLPGNPTRSYRTREP
VWIVGELTDWVGHPPEQLAAMRQGLEELRRKGLAVIYD
3D structure
PDB2hw2 Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLY A Y49 D84 Y44 D79
BS02 GLY A N38 F39 Y49 N33 F34 Y44
BS03 RFP A F39 W59 G60 N86 V87 K90 K91 M126 G129 L130 L133 F34 W54 G55 N81 V82 K85 K86 M121 G124 L125 L128 MOAD: Ki=1.07mM
PDBbind-CN: -logKd/Ki=2.97,Ki=1.07mM
Gene Ontology
Molecular Function
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:2hw2, PDBe:2hw2, PDBj:2hw2
PDBsum2hw2
PubMed18349144
UniProtA0QRS5

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