Structure of PDB 2huo Chain A

Receptor sequence
>2huoA (length=258) Species: 10090 (Mus musculus) [Search protein sequence]
FRNYTSGPLLDRVFTTYKLMHTHQTVDFVSRKRIQYGSFSYKKMTIMEAV
GMLDDLVDESDPDVDFPNSFHAFQTAEGIRKAHPDKDWFHLVGLLHDLGK
IMALWGEPQWAVVGDTFPVGCRPQASVVFCDSTFQDNPDLQDPRYSTELG
MYQPHCGLENVLMSWGHDEYLYQMMKFNKFSLPSEAFYMIRFHSFYPWHT
GGDYRQLCSQQDLDMLPWVQEFNKFDLYTKCPDLPDVESLRPYYQGLIDK
YCPGTLSW
3D structure
PDB2huo Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.99.1: inositol oxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H98 H123 D124 D253 H71 H96 D97 D226
BS02 FE A D124 H194 H220 D97 H167 H193
BS03 OH A H123 D124 H220 D253 H96 D97 H193 D226
BS04 INS A D85 S87 D88 D124 K127 G141 D142 H194 H220 S221 D58 S60 D61 D97 K100 G114 D115 H167 H193 S194
Gene Ontology
Molecular Function
GO:0004033 aldo-keto reductase (NADPH) activity
GO:0005506 iron ion binding
GO:0008199 ferric iron binding
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0046872 metal ion binding
GO:0050113 inositol oxygenase activity
Biological Process
GO:0019310 inositol catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016234 inclusion body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2huo, PDBe:2huo, PDBj:2huo
PDBsum2huo
PubMed17012379
UniProtQ9QXN5|MIOX_MOUSE Inositol oxygenase (Gene Name=Miox)

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