Structure of PDB 2htv Chain A

Receptor sequence
>2htvA (length=388) Species: 11320 (Influenza A virus) [Search protein sequence]
VIHYSSGKDLCPVKGWAPLSKDNGIRIGSRGEVFVIREPFISCSINECRT
FFLTQGALLNDKHSNGTVKDRSPFRTLMSCPIGVAPSPSNSRFESVAWSA
TACSDGPGWLTIGITGPDATAVAVLKYNGIITDTLKSWKGNIMRTQESEC
VCQDEFCYTLITDGPSDAQAFYKILKIKKGKIVSVKDVDAPGFHFEECSC
YPSGENVECVCRDNWRGSNRPWIRFNSDLDYQIGYVCSGVFGDNPRPMDS
TGSCNSPINNGKGRYGVKGFSFRYGDGVWIGRTKSLESRSGFEMVWDANG
WVSTDKDSNGVQDIIDNDNWSGYSGSFSIRGETTGRNCTVPCFWVEMIRG
QPKEKTIWTSGSSIAFCGVNSDTTGWSWPDGALLPFDI
3D structure
PDB2htv The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 E277 R292 R371 Y406
Catalytic site (residue number reindexed from 1) D70 E197 R212 R289 Y323
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D293 G297 D324 G345 R346 Y347 D213 G217 D243 G263 R264 Y265
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2htv, PDBe:2htv, PDBj:2htv
PDBsum2htv
PubMed16915235
UniProtQ6XV46

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