Structure of PDB 2hsq Chain A

Receptor sequence
>2hsqA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
MEHHHHHHMPVFHTRTIESILEPVAQQISHLVIMHEEKAIPDLTAPVAAV
QAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQS
DPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTV
AEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNT
VKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRV
LQLTSWDEDAW
3D structure
PDB2hsq Shigella applies molecular mimicry to subvert vinculin and invade host cells.
ChainA
Resolution3.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I12 V16 Q19 I20 L23 I37 P38 L40 P43 V44 A50 L54 S112 L123 F126 D127 I20 V24 Q27 I28 L31 I40 P41 L43 P46 V47 A53 L57 S115 L126 F129 D130
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0051015 actin filament binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0015629 actin cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hsq, PDBe:2hsq, PDBj:2hsq
PDBsum2hsq
PubMed17088427
UniProtP18206|VINC_HUMAN Vinculin (Gene Name=VCL)

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