Structure of PDB 2hpi Chain A

Receptor sequence
>2hpiA (length=1143) Species: 271 (Thermus aquaticus) [Search protein sequence]
LKFAHLHQHTQFSLLDGAAKLQDLLKWVKETTPEDPALAMTDHGNLFGAV
EFYKKATAMGVKPIIGYEAYVAAESRFDRKRGGYFHLTLLAKDFTGYQNL
VRLASRAYLEGFYEKPRIDREILREHAQGLIALSGCLGAEIPQFILQDRL
DLAEARLNEDLSIFGDRFFIEIQNHGLPEQKKVNQVLKEFARKYGLGMVA
TNDGHYVRKEDARAHEVLLAIQSKTTLDDPERWRFPCDEFYVKTPEEMRA
MLPEAEWGDEPFDNTVEIARMCDVDLPIGDKMVYRIPRFPLGRTEAQYLR
ELTFLGLLRRYPDRITEAFYREVLRLLDERALAEALARVEEKAWEELRKR
EWTAEAILHRALYELSVIERMGFPGYFLIVQDYINWARGHGVSVGPGRGS
AAGSLVAYAVGITNIDPLRFGLLFERFLNPERVSMPDIDTDFSDRERDRV
IQYVRERYGEDKVAQIGTFGSLASKAALKDVARVYGIPHKKAEELAKLIP
VQFGKPKPLQEAELRAEMEKDERIRQVIEVAMRLEGLNRHASVHAAGVVI
AAEPLTDLVPLMRDQEGRPVTQYDMGAVEALGLLKMDFLGLRTLTFLDEA
RRIVKESKGVELDYDRLPLDDPKTFELLSRGETKGVFQLESGGMTATVRG
LKPRRLEDIIALVSLYRPGPMEHIPTYIRRHHGQEPVSYAEFPHAEKYLR
PILDETYGIPVYQEQIMQIASQVAGYSLGEADLLRRAMGKKRVEEMQKHR
ERFVRGAKERGVPEEEANRLFDMLEAFANYGFNKSHAAAYSLLSYQTAYV
KAHYPVEFMAALLSVERHDSDKVAEYIRDARALGIPVLPPDVNRSGFDFK
VVGEEILFGLSAVKNVGEMAARAILEERERGGPFKSLGDFLKRLPEQVVN
KRALESLVKAGALDAFGDRARLLASLEPLLRWAAETRERGRSGLVGLFAE
VEEPPLVEASPLDEITMLRYEKEALGIYVSGHPVLRYPGLREVASCTIEE
LSEFVRELPGKPKVLLSGMVEEVRFTLSDETGALEVVKEDIPLLVLAEVE
RVLAQAVWTLEEVLEAPKALEVEVDHALLDEKGARLKSLLDEHPGSLPVY
LRVLGPFGEALFALREVRVGEEALGLLEAEGYRAYLVPDREVF
3D structure
PDB2hpi The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D20 H47 H214 D16 H43 H205
BS02 ZN A H11 H13 E72 D212 H7 H9 E68 D203
BS03 MG A D463 D465 K616 D618 D437 D439 K585 D587
BS04 MG A R129 E149 D169 R120 E140 D160
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hpi, PDBe:2hpi, PDBj:2hpi
PDBsum2hpi
PubMed16959569
UniProtQ9XDH5|DPO3A_THEAQ DNA polymerase III subunit alpha (Gene Name=dnaE)

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