Structure of PDB 2hma Chain A

Receptor sequence
>2hmaA (length=364) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
SDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDTDCTATED
YKDVVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNK
EIKFKAFLDYAITLGADYVATGHYARVARDEDGTVHMLRGVDNGKDQTYF
LSQLSQEQLQKTMFPLGHLEKPEVRRLAEEAGLSTAKKKDSTGICFIGEK
NFKNFLSNYLPAQPGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGDNAP
WFVVGKDLSKNILYVGQGFYHDSLMSTSLEASQVHFTREMPEEFTLECTA
KFRYRQPDSKVTVHVKGEKTEVIFAEPQRAITPGQAVVFYDGEECLGGGL
IDNAYRDGQVCQYI
3D structure
PDB2hma The Crystal Structure of tRNA (5-Methylaminomethyl-2-Thiouridylate)-Methyltransferase TrmU from Streptococcus pneumoniae
ChainA
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.1.13: tRNA-uridine 2-sulfurtransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A G16 S19 G15 S18
BS02 SAM A G12 M13 S14 S19 M38 D100 N104 K108 T126 G127 H128 F155 G11 M12 S13 S18 M37 D95 N99 K103 T121 G122 H123 F150
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016783 sulfurtransferase activity
GO:0103016 tRNA-uridine 2-sulfurtransferase activity
Biological Process
GO:0002143 tRNA wobble position uridine thiolation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hma, PDBe:2hma, PDBj:2hma
PDBsum2hma
PubMed
UniProtQ97T38|MNMA_STRPN tRNA-specific 2-thiouridylase MnmA (Gene Name=mnmA)

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