Structure of PDB 2hjh Chain A

Receptor sequence
>2hjhA (length=325) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DPLAKKQTVRLIKDLQVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAG
VSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANM
VLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCH
GSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPERPPYI
LNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSE
IVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHK
KWNDLKNKNFKCQEKDKGVYVVTSD
3D structure
PDB2hjh Autoregulation of the yeast Sir2 deacetylase by reaction and trapping of a pseudosubstrate motif in the active site
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P272 D273 F274 R275 N345 D347 H364
Catalytic site (residue number reindexed from 1) P58 D59 F60 R61 N131 D133 H150
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C372 C375 C396 C399 C158 C161 C182 C185
BS02 XYQ A K222 G262 A263 G264 T267 D273 F274 R275 Q344 H364 G471 T472 S473 N496 R497 D498 Y512 C513 K13 G48 A49 G50 T53 D59 F60 R61 Q130 H150 G240 T241 S242 N265 R266 D267 Y281 C282
BS03 NCA A I271 P272 F274 I57 P58 F60 BindingDB: IC50=<50000nM
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:2hjh, PDBe:2hjh, PDBj:2hjh
PDBsum2hjh
PubMed
UniProtP06700|SIR2_YEAST NAD-dependent histone deacetylase SIR2 (Gene Name=SIR2)

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