Structure of PDB 2hiw Chain A

Receptor sequence
>2hiwA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
GAMDPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE
DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLD
YLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH
LVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAF
GVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC
WQWNPSDRPSFAEIHQAFETMFQE
3D structure
PDB2hiw A general strategy for creating
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D381 A383 R385 N386 D399 P420
Catalytic site (residue number reindexed from 1) D138 A140 R142 N143 D156 P177
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7MP A L266 Y271 V274 A287 K289 E304 M308 V317 I331 T333 M336 H379 L388 A398 D399 F400 L23 Y28 V31 A44 K46 E61 M65 V74 I88 T90 M93 H136 L145 A155 D156 F157 MOAD: ic50=8nM
PDBbind-CN: -logKd/Ki=8.10,IC50=8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2hiw, PDBe:2hiw, PDBj:2hiw
PDBsum2hiw
PubMed16873026
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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