Structure of PDB 2hfz Chain A

Receptor sequence
>2hfzA (length=608) Species: 11077 (Kunjin virus) [Search protein sequence]
SDTSKIKNRIERLRREYSSTWHHDENHPYRTWNYHGSYEVKPTGSASSLV
NGVVRLLSKPWDTITNVTTMAMTDTTPFGQQRVFKEKVDTKAPEPPEGVK
YVLNETTNWLWAFLAREKRPRMCSREEFIRKVNSNAEEQNQWRSAREAVE
DPKFWEMVDEEREAHLRGECHTCIYNMMGKGSRAIWFMWLGARFLEFEAL
GFLNEDHWLGRKNSGGGVEGLGLQKLGYILREVGTRPGGRIYADDTAGWD
TRITRADLENEAKVLELLDGEHRRLARAIIELTYRHKVVKVMRPAADGRT
VMDVISREDQRGSGQVVTYALNTFTNLAVQLVRMMEGEGVIGPDDVEKLT
KGKGPKVRTWLSENGEERLSRMAVSGDDCVVKPLDDRFATSLHFLNAMSK
VRKDIQEWKPSTGWYDWQQVPFCSNHFTELIMKDGRTLVTPCRGQDELVG
RARISPGAGWNVRDTACLAKSYAQMWLLLYFHRRDLRLMANAICSAVPVN
WVPTGRTTWSIHAGGEWMTTEDMLEVWNRVWIEENEWMEDKTPVEKWSDV
PYSGKREDIWCGSLIGTRARATWAENIQVAINQVRSIIGDEKYVDYMSSL
KRYEDTTL
3D structure
PDB2hfz Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A A534 D536 A243 D245
BS02 ZN A E440 H444 E161 H165
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2hfz, PDBe:2hfz, PDBj:2hfz
PDBsum2hfz
PubMed17287213
UniProtP14335|POLG_KUNJM Genome polyprotein

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