Structure of PDB 2hfk Chain A

Receptor sequence
>2hfkA (length=280) Species: 54571 (Streptomyces venezuelae) [Search protein sequence]
AGMFRALFRQAVEDDRYGEFLDVLAEASAFRPQFASPEACSERLDPVLLA
GGPTDAEGRAVLVGCTGTAANGGPHEFLRLSTSFQEERDFLAVPLPGYGT
GGTALLPADLDTALDAQARAILRAAGDAPVVLLGHAGGALLAHELAFRLE
RAHGAPPAGIVLVDPYPPGHQEPIEVWSRQLGEGLFAGELEPMSDARLLA
MGRYARFLAGPRPGRSSAPVLLVRASEPLGDWQEERGDWRAHWDLPHTVA
DVPGDHFTMMRDHAPAVAEAVLSWLDAIEG
3D structure
PDB2hfk Structural Basis for Macrolactonization by the Pikromycin Thioesterase
ChainA
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A148 G149 D176 H268
Catalytic site (residue number reindexed from 1) A136 G137 D164 H256
Enzyme Commision number 2.3.1.239: 10-deoxymethynolide syntase.
2.3.1.240: narbonolide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A H254 D256 H242 D244
BS02 E4H A Y25 G26 L29 I186 A217 Y17 G18 L21 I174 A205
Gene Ontology
Biological Process
GO:0009058 biosynthetic process

View graph for
Biological Process
External links
PDB RCSB:2hfk, PDBe:2hfk, PDBj:2hfk
PDBsum2hfk
PubMed16969372
UniProtQ9ZGI2|PIKA4_STRVZ Narbonolide/10-deoxymethynolide synthase PikA4, module 6 (Gene Name=pikAIV)

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