Structure of PDB 2hdp Chain A

Receptor sequence
>2hdpA (length=63) Species: 9606 (Homo sapiens) [Search protein sequence]
SLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVC
RQPIQMIVLTYFP
3D structure
PDB2hdp Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53.
ChainA
ResolutionN/A
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H452 H457 C475 C478 H24 H29 C47 C50
BS02 ZN A C438 C441 C464 C10 C13 C36
Gene Ontology
Molecular Function
GO:0042802 identical protein binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2hdp, PDBe:2hdp, PDBj:2hdp
PDBsum2hdp
PubMed16965791
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

[Back to BioLiP]