Structure of PDB 2hdd Chain A

Receptor sequence
>2hddA (length=55) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
RTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFKNKRA
KIKKS
3D structure
PDB2hdd Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R5 T6 F8 Q44 N51 R1 T2 F4 Q40 N47 PDBbind-CN: Kd=8.8pM
BS02 dna A Y25 R31 K50 R53 Y21 R27 K46 R49 PDBbind-CN: Kd=8.8pM
Gene Ontology
Molecular Function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2hdd, PDBe:2hdd, PDBj:2hdd
PDBsum2hdd
PubMed9309220
UniProtP02836|HMEN_DROME Segmentation polarity homeobox protein engrailed (Gene Name=en)

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