Structure of PDB 2hd1 Chain A

Receptor sequence
>2hd1A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSI
NPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQT
DILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF
QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME
NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDR
EKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKK
3D structure
PDB2hd1 Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor IBMX binding
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H256 H292 D293 D402 H76 H112 D113 D222
BS02 IBM A I403 L420 Y424 Q453 F456 I223 L240 Y244 Q273 F276 MOAD: ic50~500uM
PDBbind-CN: -logKd/Ki=3.30,IC50=500uM
BindingDB: IC50=>200000nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:2hd1, PDBe:2hd1, PDBj:2hd1
PDBsum2hd1
PubMed15210993
UniProtO76083|PDE9A_HUMAN High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Gene Name=PDE9A)

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