Structure of PDB 2hc9 Chain A

Receptor sequence
>2hc9A (length=489) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
TQVLVRNGIQAVGDGLTSLIIVGKKSVLKNVTFEGKFKEVAQKFVTDGDS
WNSMISRIPASGRHPLHYELAHLITVPDASSRGNTPTNAHSIYKELKPIN
YPEDTKNVHFVLFAEYPDVLSHVAAIARTFCKFSMKTSGIRELNVNIDVV
CDKLTNEDAVFLTDLSESVRETARLIDTPANILTTDALVDEAVKVGNATG
SKITVIRGEELLKAGFGGIYHVGKAGPTPPAFVVLSHEVPGSTEHIALVG
KGVVYDTGGLQIKTKTGMPNMKRDMGGAAGMLEAYSALVKHGFSQTLHAC
LCIVENNVSPIANKPDDIIKMLSGKTVEINNTDAEGRLILADGVFYAKET
LKATTIFDMATLTGAQAWLSGRLHGAAMTNDEQLENEIIKAGKASGDLVA
PMLFAPDLFFGDLKSSIADMKNSNLGKMDGPPSAVAGLLIGAHIGFGEGL
RWLHLDIAAPAEVGDRGTGYGPALFSTLLGKYTSVPMLK
3D structure
PDB2hc9 Crystal Structure and Function of Caenorhabditis Elegans Leucine Aminopeptidase
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K264 R338
Catalytic site (residue number reindexed from 1) K263 R337
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D257 D334 E336 D256 D333 E335
BS02 ZN A K252 D257 D275 E336 K251 D256 D274 E335
BS03 BCT A A335 E336 G337 R338 L363 A334 E335 G336 R337 L362
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
GO:0040009 regulation of growth rate
GO:0046662 regulation of egg-laying behavior
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hc9, PDBe:2hc9, PDBj:2hc9
PDBsum2hc9
PubMed
UniProtP34629|AMPL_CAEEL Leucine aminopeptidase 1 (Gene Name=lap-1)

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