Structure of PDB 2hbr Chain A

Receptor sequence
>2hbrA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
TSSGSEGNVKLCSLEEAQRIAEIYPIMDKSSRTRLALIICNEEFDSIPRR
TGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS
TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKV
IIIQACAGDSPGVVWFKD
3D structure
PDB2hbr A Common Allosteric Site and Mechanism in Caspases
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P177 H237 G238 C285 A286
Catalytic site (residue number reindexed from 1) P48 H108 G109 C156 A157
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R179 H237 Q283 C285 R50 H108 Q154 C156
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2hbr, PDBe:2hbr, PDBj:2hbr
PDBsum2hbr
PubMed16682620
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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