Structure of PDB 2hbm Chain A

Receptor sequence
>2hbmA (length=390) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GMVEKPQLKFKSPIDNSESHPFIPLLKEKPNALKPLSESLRLVDDDENNP
SHYPHPYEYEIDHQEYSPEILQIREEIPSKSWDDSVPIWVDTSTELESML
EDLKNTKEIAVDLEHHDYRSYYGIVCLMQISTRERDYLVDTLKLRENLHI
LNEVFTNPSIVKVFHGAFMDIIWLQRDLGLYVVGLFDTYHASKAIGLPRH
SLAYLLENFANFKTSKKYQLADWRIRPLSKPMTAAARADTHFLLNIYDQL
RNKLIESNKLAGVLYESRNVAKRRFEYSKYRPLTPSSEVYSPIEKESPWK
ILMYQYNIPPEREVLVRELYQWRDLIARRDDESPRFVMPNQLLAALVAYT
PTDVIGVVSLTNGVTEHVRQNAKLLANLIRDALRNIKNTN
3D structure
PDB2hbm Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D238 E240 D296 A361 D365
Catalytic site (residue number reindexed from 1) D112 E114 D170 A235 D239
Enzyme Commision number 3.1.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D238 E240 D365 D112 E114 D239
BS02 U A E240 H241 K342 Q345 W349 E114 H115 K216 Q219 W223
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006139 nucleobase-containing compound metabolic process
GO:0044237 cellular metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2hbm, PDBe:2hbm, PDBj:2hbm
PDBsum2hbm
PubMed16882719
UniProtQ12149|RRP6_YEAST Exosome complex exonuclease RRP6 (Gene Name=RRP6)

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