Structure of PDB 2hb3 Chain A

Receptor sequence
>2hb3A (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGI
GGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF
3D structure
PDB2hb3 Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance.
ChainA
Resolution1.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 3.4.23.4: chymosin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GRL A D25 A28 D30 V82 I84 D25 A28 D30 V82 I84 PDBbind-CN: -logKd/Ki=11.35,Ki=4.5pM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2hb3, PDBe:2hb3, PDBj:2hb3
PDBsum2hb3
PubMed16913714
UniProtQ7SSI0

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