Structure of PDB 2haw Chain A

Receptor sequence
>2hawA (length=307) Species: 1423 (Bacillus subtilis) [Search protein sequence]
EKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNGETQYALD
YFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIA
NFETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSL
LFKSPTCTDQDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELIS
LDAKEFTLGSKKVEIAQVNTVDIEDVKKRQAELEAVISKVVAEKNLDLFL
LVITDILENDSLALAIGNEAAKVEKAFNVTLENNTALLKGVVSRKKQVVP
VLTDAMA
3D structure
PDB2haw A trimetal site and substrate distortion in a family II inorganic pyrophosphatase
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.1: inorganic diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A H9 D13 D75 H8 D12 D74
BS02 MG A D15 D75 H97 D149 D14 D74 H96 D148
BS03 MG A D13 D149 D12 D148
BS04 F A D13 D15 D75 D149 D12 D14 D74 D148
BS05 2PN A D13 D75 H97 H98 K205 R295 K296 D12 D74 H96 H97 K204 R294 K295 MOAD: Kd=12uM
PDBbind-CN: -logKd/Ki=4.92,Kd=12uM
Gene Ontology
Molecular Function
GO:0004427 inorganic diphosphate phosphatase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:2haw, PDBe:2haw, PDBj:2haw
PDBsum2haw
PubMed17095506
UniProtP37487|PPAC_BACSU Manganese-dependent inorganic pyrophosphatase (Gene Name=ppaC)

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