Structure of PDB 2ha8 Chain A

Receptor sequence
>2ha8A (length=159) Species: 9606 (Homo sapiens) [Search protein sequence]
LGKSISRLIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCISDKQFQ
HLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTIIGVEQTAKSLDLTQYC
FPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIW
EYTRQQLLS
3D structure
PDB2ha8 The Crystal Structure of Methyltransferase Domain of Human TAR (HIV-1) RNA binding protein 1 in complex with S-adenosyl-L-homocystein.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A V106 E107 Q108 G129 N130 E131 E148 I149 Q151 R156 S157 L158 V160 S163 V87 E88 Q89 G110 N111 E112 E129 I130 Q132 R137 S138 L139 V141 S144
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008173 RNA methyltransferase activity
GO:0016423 tRNA (guanine) methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0030488 tRNA methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2ha8, PDBe:2ha8, PDBj:2ha8
PDBsum2ha8
PubMed
UniProtQ13395|TARB1_HUMAN Probable methyltransferase TARBP1 (Gene Name=TARBP1)

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