Structure of PDB 2h9h Chain A

Receptor sequence
>2h9hA (length=212) Species: 12092 (Hepatovirus A) [Search protein sequence]
STLEIAGLVRKNLVQFGVGEKNGSVRWVMNALGVKDDWLLVPSHAYKFEK
DYEMMEFYFNRGGTYYSISAGNVVIQSLDVGFQDVVLMKVPTIPKFRDIT
QHFIKKGDVPRALNRLATLVTTVNGTPMLISEGPLKMEEKATYVHKKNDG
TTVDLTVDQAWRGKGEGLPGMCGGALVSSNQSIQNAILGIHVAGGNSILV
AKLVTQEMFQNI
3D structure
PDB2h9h An Episulfide Cation (Thiiranium Ring) Trapped in the Active Site of HAV 3C Proteinase Inactivated by Peptide-based Ketone Inhibitors.
ChainA
Resolution1.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H44 Y143 V144 H145 G167 G170 C172 V192 A193 G194 I198 V200 H44 Y143 V144 H145 G167 G170 C172 V192 A193 G194 I198 V200
BS02 BBL A H44 R97 H102 C172 H44 R97 H102 C172
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h9h, PDBe:2h9h, PDBj:2h9h
PDBsum2h9h
PubMed16860823
UniProtP08617|POLG_HAVHM Genome polyprotein

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