Structure of PDB 2h8a Chain A

Receptor sequence
>2h8aA (length=121) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NEVLMAFTSYATIILAKMMFLSSATAFQRLTNKVFLRTDEKVERVRRAHL
NDLENIVPFLGIGLLYSLSGPDLSTALIHFRIFVGARIYHTIAYLTPLPQ
PNRGLAFFVGYGVTLSMAYRL
3D structure
PDB2h8a Structural basis for detoxification and oxidative stress protection in membranes.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A R73 L124 R47 L98
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0043295 glutathione binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0032496 response to lipopolysaccharide
GO:0033327 Leydig cell differentiation
GO:0034635 glutathione transport
GO:0071449 cellular response to lipid hydroperoxide
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0045177 apical part of cell

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h8a, PDBe:2h8a, PDBj:2h8a
PDBsum2h8a
PubMed16806268
UniProtP08011|MGST1_RAT Microsomal glutathione S-transferase 1 (Gene Name=Mgst1)

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