Structure of PDB 2h7y Chain A

Receptor sequence
>2h7yA (length=280) Species: 54571 (Streptomyces venezuelae) [Search protein sequence]
AGMFRALFRQAVEDDRYGEFLDVLAEASAFRPQFASPEACSERLDPVLLA
GGPTDAEGRAVLVGCTGTAANGGPHEFLRLSTSFQEERDFLAVPLPGYGT
GGTALLPADLDTALDAQARAILRAAGDAPVVLLGHSGGALLAHELAFRLE
RAHGAPPAGIVLVDPYPPGHQEPIEVWSRQLGEGLFAGELEPMSDARLLA
MGRYARFLAGPRPGRSSAPVLLVRASEPLGDWQEERGDWRAHWDLPHTVA
DVPGDHFTMMRDHAPAVAEAVLSWLDAIEG
3D structure
PDB2h7y Structural and Mechanistic Insights of Polyketide Macrolactonization from Polyketide-based Affinity Labels
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S148 G149 D176 H268
Catalytic site (residue number reindexed from 1) S136 G137 D164 H256
Enzyme Commision number 2.3.1.239: 10-deoxymethynolide syntase.
2.3.1.240: narbonolide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A H254 D256 H242 D244
BS02 PSK A S148 G149 H268 S136 G137 H256
Gene Ontology
Biological Process
GO:0009058 biosynthetic process

View graph for
Biological Process
External links
PDB RCSB:2h7y, PDBe:2h7y, PDBj:2h7y
PDBsum2h7y
PubMed16969373
UniProtQ9ZGI2|PIKA4_STRVZ Narbonolide/10-deoxymethynolide synthase PikA4, module 6 (Gene Name=pikAIV)

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