Structure of PDB 2h54 Chain A

Receptor sequence
>2h54A (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
TSSGSEGNVKLCSLEEAQRIWSAEIYPIMDKSSRTRLALIICNEEFDSIP
RRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTS
DSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP
KVIIIQACRGDSPGVVWFKD
3D structure
PDB2h54 An allosteric circuit in caspase-1.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P177 R178 H237 G238 C285 R286
Catalytic site (residue number reindexed from 1) P50 R51 H110 G111 C158 R159
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R179 H237 C285 R52 H110 C158
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h54, PDBe:2h54, PDBj:2h54
PDBsum2h54
PubMed18590738
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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