Structure of PDB 2h4z Chain A

Receptor sequence
>2h4zA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
SKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFE
FDLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNRE
QMALNHGEEQVRLWRRSYNVTPPPIEESHPYYQEIYNDRRYKVCDVPLDQ
LPRSESLKDVLERLLPYWNERIAPEVLRGKTILISAHGNSSRALLKHLEG
ISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQ
GKVKQ
3D structure
PDB2h4z Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H11 R62 E89 H188
Catalytic site (residue number reindexed from 1) H10 R61 E88 H187
Enzyme Commision number 5.4.2.11: phosphoglycerate mutase (2,3-diphosphoglycerate-dependent).
5.4.2.4: bisphosphoglycerate mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DG2 A R10 H11 C23 S24 R62 E89 Y92 R100 R116 R117 H188 N190 R9 H10 C22 S23 R61 E88 Y91 R99 R115 R116 H187 N189
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004082 bisphosphoglycerate mutase activity
GO:0004619 phosphoglycerate mutase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046538 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0006753 nucleoside phosphate metabolic process
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0015671 oxygen transport
GO:0033554 cellular response to stress
GO:0042832 defense response to protozoan
GO:0048821 erythrocyte development
GO:0060856 establishment of blood-brain barrier
GO:0150076 neuroinflammatory response
GO:1901136 carbohydrate derivative catabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h4z, PDBe:2h4z, PDBj:2h4z
PDBsum2h4z
PubMed17052986
UniProtP07738|PMGE_HUMAN Bisphosphoglycerate mutase (Gene Name=BPGM)

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