Structure of PDB 2h4y Chain A

Receptor sequence
>2h4yA (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
NVKLCSLEEAQRIWSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEV
DITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVF
MSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQA
CKGDSPGVVWFKD
3D structure
PDB2h4y An allosteric circuit in caspase-1.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P177 R178 H237 G238 C285 K286
Catalytic site (residue number reindexed from 1) P43 R44 H103 G104 C151 K152
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R179 H237 Q283 C285 R45 H103 Q149 C151
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h4y, PDBe:2h4y, PDBj:2h4y
PDBsum2h4y
PubMed18590738
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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