Structure of PDB 2h4w Chain A

Receptor sequence
>2h4wA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
TSSGSEGNVKLCSLEEAQRIAEIYPIMDKSSRTRLALIICNEEFDSIPRR
TGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS
TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKV
IIIQACRGDSPGVVWFKD
3D structure
PDB2h4w An allosteric circuit in caspase-1.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P177 R178 H237 G238 C285 R286
Catalytic site (residue number reindexed from 1) P48 R49 H108 G109 C156 R157
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R179 H237 Q283 C285 R50 H108 Q154 C156
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h4w, PDBe:2h4w, PDBj:2h4w
PDBsum2h4w
PubMed18590738
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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