Structure of PDB 2h4m Chain A

Receptor sequence

>2h4mA (length=827) Species: 9606 (Homo sapiens)

KPDEQGLQQILQLLKESQSPDTTIQRTVQQKPDFNNYLIFVLTKLKSEDE
PTRSLSGLILKNNVKFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILI
TTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILD
SDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHID
SFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQR
TQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDID
IILLKTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVV
KESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLS
RYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACT
ELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQ
MLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCV
NLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLV
ARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPIL
GTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNT
PKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSA
FRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQ
VGDENWRRFSDQFPLPLKERLAAFYGV

3D structure

• PDB: 2h4m Rules for nuclear localization sequence recognition by karyopherin beta 2.
• Chain: A
• Resolution: 3.05 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	K377 A381 D384 W460 E498 S502 E509 I540 D543 T547 F584 D639 V643 Q685 N726 N727 W730 T766 E769 N770 I773 R777 N803 I804 R805 E809	K314 A318 D321 W397 E435 S439 E446 I477 D480 T484 F521 D576 V580 Q622 N663 N664 W667 T703 E706 N707 I710 R714 N740 I741 R742 E746

Gene Ontology

Molecular Function

• GO:0031267 small GTPase binding

Biological Process

• GO:0006606 protein import into nucleus
• GO:0006886 intracellular protein transport

External links

• PDB: RCSB:2h4m, PDBe:2h4m, PDBj:2h4m
• PDBsum: 2h4m
• PubMed: 16901787
• UniProt: Q92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)