Structure of PDB 2h2f Chain A

Receptor sequence
>2h2fA (length=234) Species: 2336 (Thermotoga maritima) [Search protein sequence]
MKMKEFLDLLNESRLTVTLTGAGISTPSGIPDQNVFDIDFFYSHPEEFYR
FAKEGIFPMLQAKPNLAHVLLAKLEEKGLIEAVITQNIDRLHQRAGSKKV
IELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFF
GENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVI
VNLGETPFDDIATLKYNMDVVEFARRVMEEGGIS
3D structure
PDB2h2f The structural basis of sirtuin substrate affinity
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P31 D32 N99 D101 H116
Catalytic site (residue number reindexed from 1) P31 D32 N87 D89 H104
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V160 F162 G163 E164 N165 L166 V193 Y194 P195 V148 F150 G151 E152 N153 L154 V181 Y182 P183
BS02 ZN A C124 C148 C112 C136
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0017136 NAD-dependent histone deacetylase activity
GO:0034979 NAD-dependent protein lysine deacetylase activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0006338 chromatin remodeling
GO:0006476 protein deacetylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h2f, PDBe:2h2f, PDBj:2h2f
PDBsum2h2f
PubMed16768447
UniProtQ9WYW0|NPD_THEMA NAD-dependent protein deacetylase (Gene Name=cobB)

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