Structure of PDB 2h04 Chain A

Receptor sequence
>2h04A (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPEN
RGKNRYNNILPYDATRVKLSNSDYINASYIPGNNFRREYIVTQGPLPGTK
DDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQML
SESVLPEWTIREFKICGEHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVR
DYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHD
LRLHRVHMVQTECQYVYLHQCVRDVLRARK
3D structure
PDB2h04 Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1870 C1904 R1910 T1911 Q1948
Catalytic site (residue number reindexed from 1) D182 C216 R222 T223 Q260
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4UN A Y1733 N1735 D1870 H1871 C1904 S1905 A1906 V1908 R1910 H1945 Y56 N58 D182 H183 C216 S217 A218 V220 R222 H257 MOAD: ic50=0.07uM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2h04, PDBe:2h04, PDBj:2h04
PDBsum2h04
PubMed16759857
UniProtP23467|PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (Gene Name=PTPRB)

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