Structure of PDB 2h02 Chain A

Receptor sequence
>2h02A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPEN
RGKNRYNNILPYDATRVKLSSDYINASYIPGNNFRREYIVTQGPLPGTKD
DFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLS
ESVLPEWTIREFKICGEHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRD
YINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDL
RLHRVHMVQTECQYVYLHQCVRDVLRAR
3D structure
PDB2h02 Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1870 C1904 R1910 T1911 Q1948
Catalytic site (residue number reindexed from 1) D181 C215 R221 T222 Q259
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2UN A Y1733 N1735 D1870 H1871 C1904 S1905 A1906 V1908 G1909 R1910 Q1948 Y56 N58 D181 H182 C215 S216 A217 V219 G220 R221 Q259 MOAD: ic50=0.32uM
PDBbind-CN: -logKd/Ki=6.49,IC50=0.32uM
BindingDB: IC50=320nM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2h02, PDBe:2h02, PDBj:2h02
PDBsum2h02
PubMed16759857
UniProtP23467|PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (Gene Name=PTPRB)

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