Structure of PDB 2h00 Chain A

Receptor sequence
>2h00A (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
VSLNFKDPEAVRALTCTLLREDFGLSIDIPLERLIPTVPLRLNYIHWVED
LIGHQDSDKSTLRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNY
AKKNVEQNNLSDLIKVVKVPQKTLLMDALKEESEIIYDFCMCNPPFFGIT
EIMAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKEELRIQG
VPKVTYTEFCQGRTMRWALAWSFYD
3D structure
PDB2h00 The Crystal Structure of Human methyltransferase 10 domain containing protein.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.346: U6 snRNA m(6)A methyltransferase.
2.1.1.348: mRNA m(6)A methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A L38 R45 G73 T74 E96 V97 Q125 N147 F151 L34 R41 G69 T70 E92 V93 Q121 N143 F147
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2h00, PDBe:2h00, PDBj:2h00
PDBsum2h00
PubMed
UniProtQ86W50|MET16_HUMAN RNA N6-adenosine-methyltransferase METTL16 (Gene Name=METTL16)

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