Structure of PDB 2gwr Chain A

Receptor sequence
>2gwrA (length=225) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
DTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPD
LVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADD
YIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQ
ISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRADTRLVNVHVQRLRA
KVEKDPENPTVVLTVRGVGYKAGPP
3D structure
PDB2gwr Domain orientation in the inactive response regulator Mycobacterium tuberculosis MtrA provides a barrier to activation.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D13 D56 M58 D12 D55 M57
Gene Ontology
Molecular Function
GO:0000156 phosphorelay response regulator activity
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0051701 biological process involved in interaction with host
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0032993 protein-DNA complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2gwr, PDBe:2gwr, PDBj:2gwr
PDBsum2gwr
PubMed17511470
UniProtP9WGM7|MTRA_MYCTU DNA-binding response regulator MtrA (Gene Name=mtrA)

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