Structure of PDB 2gwh Chain A

Receptor sequence
>2gwhA (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
RLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTWTQEIV
ELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKTH
LPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEY
FETFLAGKVCWGSWHEHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLA
EFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEIMDHSISPFMRK
GAVGDWKKHFTVAQNERFDEDYKKKMTRLTFHFQF
3D structure
PDB2gwh Structural and chemical profiling of the human cytosolic sulfotransferases.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K55 H115 S145
Catalytic site (residue number reindexed from 1) K40 H100 S130
Enzyme Commision number 2.8.2.1: aryl sulfotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A3P A K55 T58 T59 W60 R137 S145 Y200 F236 M263 R264 K265 G266 K40 T43 T44 W45 R122 S130 Y185 F221 M248 R249 K250 G251
BS02 PCI A F88 K113 H115 F149 N153 L156 W176 Y247 M255 F73 K98 H100 F134 N138 L141 W161 Y232 M240
Gene Ontology
Molecular Function
GO:0004062 aryl sulfotransferase activity
GO:0008146 sulfotransferase activity
GO:0016740 transferase activity
Biological Process
GO:0006068 ethanol catabolic process
GO:0006805 xenobiotic metabolic process
GO:0009812 flavonoid metabolic process
GO:0044598 doxorubicin metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2gwh, PDBe:2gwh, PDBj:2gwh
PDBsum2gwh
PubMed17425406
UniProtO75897|ST1C4_HUMAN Sulfotransferase 1C4 (Gene Name=SULT1C4)

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