Structure of PDB 2gvd Chain A

Receptor sequence
>2gvdA (length=190) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDK
LAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVRE
MTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGR
IHITKATLSYLNGDYEVEPGCGGERNAYLKEHSIETFLIL
3D structure
PDB2gvd Broad specificity of Mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D396 I397 D440 H516
Catalytic site (residue number reindexed from 1) D21 I22 D65 H141
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D396 D440 D21 D65
BS02 MN A D396 I397 D440 D21 I22 D65
BS03 FKP A C441 V506 W507 S508 V511 T512 N515 C66 V131 W132 S133 V136 T137 N140
BS04 128 A I397 G399 F400 A409 L412 G439 D440 R484 I22 G24 F25 A34 L37 G64 D65 R109 PDBbind-CN: -logKd/Ki=7.00,Ki=100nM
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:2gvd, PDBe:2gvd, PDBj:2gvd
PDBsum2gvd
PubMed16766715
UniProtP30803|ADCY5_CANLF Adenylate cyclase type 5 (Gene Name=ADCY5)

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