Structure of PDB 2gv2 Chain A

Receptor sequence
>2gv2A (length=88) Species: 9606 (Homo sapiens) [Search protein sequence]
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQ
3D structure
PDB2gv2 Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L54 G58 Q59 I61 M62 Q72 H73 V93 H96 Y100 L30 G34 Q35 I37 M38 Q48 H49 V69 H72 Y76
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:2gv2, PDBe:2gv2, PDBj:2gv2
PDBsum2gv2
PubMed16925398
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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