Structure of PDB 2gtq Chain A

Receptor sequence

>2gtqA (length=864) Species: 122586 (Neisseria meningitidis MC58)

TVHYLKDYQTPAYHILKTDLHFDINEPQTVVKSRLTVEPQRVGEPLVLDG
SAKLLSVKINGAAADYVLEGETLTIAGVPSERFTVEVETEILPAENKSLM
GLYASGGNLFTQCEPEGFRKITFYIDRPDVMSKFTTTIVADKKRYPVLLS
NGNKIDGGEFSDGRHWVKWEDPFSKPSYLFALVAGDLAVTEDYFTTMSGR
NVKIEFYTTEADKPKVGFAVESLKNAMKWDETRFGLEYDLDIFMVVAVGD
FNMGAMENKGLNIFNTKFVLADSRTATDTDFEGIESVVGHEYFHNWTGNR
VTCRDWFQLSLKEGLTVFRDQEFSGDRASRAVRRIENIRLLRQHQFPEDA
GPTAHPVRPASYEEMNNFYTMTVYEKGAEVVRMYHTLLGEEGFQKGMKLY
FQRHDGQAVTCDDFRAAMADANGINLDQFALWYSQAGTPVLEAEGRLKNN
IFELTVKQTVPPTPDMTDKQPMMIPVKVGLLNRNGEAVAFDYQGKRATEA
VLLLTEAEQTFLLEGVTEAVVPSLLRGFSAPVHLNYPYSDDDLLLLLAHD
SDAFTRWEAAQTLYRRAVAANLATLSDGVELPKHEKLLAAVEKVISDDLL
DNAFKALLLGVPSEAELWDGAENIDPLRYHQAREALLDTLAVHFLPKWHE
LNRQAAKQENQSYEYSPEAAGWRTLRNVCRAFVLRADPAHIETVAEKYGE
MAQNMTHEWGILSAVNGNESDTRNRLLAQFADKFSDDALVMDKYFALVGS
SRRSDTLQQVRTALQHPKFSLENPNKARSLIGSFSRNVPHFHAEDGSGYR
FIADKVIEIDRFNPQVAARLVQAFNLCNKLEPHRKNLVKQALQRIRAQEG
LSKDVGEIVGKILD

3D structure

• PDB: 2gtq Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis.
• Chain: A
• Resolution: 2.05 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E260 H293 E294 H297 E316 N369 Y377
• Catalytic site (residue number reindexed from 1): E257 H290 E291 H294 E313 N366 Y374
• Enzyme Commision number: 3.4.11.2: membrane alanyl aminopeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H293 H297 E316	H290 H294 E313

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:2gtq, PDBe:2gtq, PDBj:2gtq
• PDBsum: 2gtq
• PubMed: 17876832
• UniProt: Q9JYV4