Structure of PDB 2gqs Chain A

Receptor sequence
>2gqsA (length=237) Species: 562 (Escherichia coli) [Search protein sequence]
MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVN
NKFNYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGS
LVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLAR
MKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSPDGSRL
WDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
3D structure
PDB2gqs Nucleotide Complexes of Escherichia coli Phosphoribosylaminoimidazole Succinocarboxamide Synthetase.
ChainA
Resolution2.05 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E90 D129 E90 D129
BS02 MG A E90 D129 E90 D129
BS03 ADP A Y8 G10 K11 A12 K13 L24 Q69 L84 M86 K123 E179 D191 Y8 G10 K11 A12 K13 L24 Q69 L84 M86 K123 E179 D191
BS04 C2R A E90 R94 G99 S100 D175 K177 D196 G197 S198 R199 R215 E90 R94 G99 S100 D175 K177 D196 G197 S198 R199 R215
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009236 cobalamin biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2gqs, PDBe:2gqs, PDBj:2gqs
PDBsum2gqs
PubMed16687397
UniProtP0A7D7|PUR7_ECOLI Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=purC)

[Back to BioLiP]