Structure of PDB 2gq3 Chain A

Receptor sequence
>2gq3A (length=720) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQ
ALLNARDELQAQIDKWHRRRPIDMDAYRQFLTEIGYLLPEPDDFTITTSG
VDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGA
EKGPTYNKVRGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLVVAL
PDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIEILIDPESQVGTTDR
AGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLAAAVD
KDGTAFLRVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTD
GSEVFEGIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPKMHGPA
EVAFTCELFSRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAADRVV
FINTGFLDRTGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAG
FSGRAQVGKGMWTMTELMADMVETKIAQPRAGASTAWVPSPTAATLHALH
YHQVDVAAVQQGLAGKRRATIEQLLTIPLAKWAPDEIREEVDNNCQSILG
YVVRWVDQGVGCSKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSAD
VRASLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLAAQELILSGAQQPN
GYTEPILHRRRREFKARAAE
3D structure
PDB2gq3 The product complex of M. tuberculosis malate synthase revisited.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D271 E273 R339 E434 D462 D633
Catalytic site (residue number reindexed from 1) D267 E269 R335 E430 D458 D626
Enzyme Commision number 2.3.3.9: malate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E434 D462 E430 D458
BS02 MG A H374 K377 N382 G383 L385 H370 K373 N378 G379 L381
BS03 COA A V118 V119 R125 F126 N129 A130 K305 R312 P543 P545 C619 M631 D633 V114 V115 R121 F122 N125 A126 K301 R308 P539 P541 C612 M624 D626
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001968 fibronectin binding
GO:0003824 catalytic activity
GO:0004474 malate synthase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0016740 transferase activity
GO:0042803 protein homodimerization activity
GO:0043236 laminin binding
GO:0046810 host cell extracellular matrix binding
GO:0046872 metal ion binding
GO:0120225 coenzyme A binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0009436 glyoxylate catabolic process
GO:0015936 coenzyme A metabolic process
GO:0044406 adhesion of symbiont to host
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0009986 cell surface
GO:0042603 capsule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2gq3, PDBe:2gq3, PDBj:2gq3
PDBsum2gq3
PubMed16877713
UniProtP9WK17|MASZ_MYCTU Malate synthase G (Gene Name=glcB)

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