Structure of PDB 2gq1 Chain A

Receptor sequence
>2gq1A (length=310) Species: 562 (Escherichia coli) [Search protein sequence]
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKLDLFANEK
LKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNV
SVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTG
CGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIK
FCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRL
LYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDV
ERFIREFPDA
3D structure
PDB2gq1 Novel Allosteric Activation Site in Escherichia coli Fructose-1,6-bisphosphatase.
ChainA
Resolution1.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D66 E89 E90 D110 L112 D113 E275
Catalytic site (residue number reindexed from 1) D44 E67 E68 D88 L90 D91 E253
Enzyme Commision number 3.1.3.11: fructose-bisphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A K269 R308 K247 R286
BS02 SO4 A T3 G5 K30 T3 G5 K30
BS03 SO4 A N206 Y239 Y259 N184 Y217 Y237
BS04 SO4 A A18 G20 E21 A18 G20 E21
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005986 sucrose biosynthetic process
GO:0006000 fructose metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0030388 fructose 1,6-bisphosphate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2gq1, PDBe:2gq1, PDBj:2gq1
PDBsum2gq1
PubMed16670087
UniProtP0A993|F16PA_ECOLI Fructose-1,6-bisphosphatase class 1 (Gene Name=fbp)

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