Structure of PDB 2gpv Chain A

Receptor sequence

>2gpvA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]

KPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIG
WAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYI
MDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMH
IEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKA
VQHFYNIKLEGKVPMHKLFLEMLE

3D structure

PDB

2gpv X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Chain

Resolution

2.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I280 M298 W305	I49 M67 W74
BS02	OHT	A	C269 A272 D273 E275 M306 Y326 L345 F435	C38 A41 D42 E44 M75 Y95 L114 F204	BindingDB: IC50=1350nM,EC50=15nM

External links

PDB	RCSB:2gpv, PDBe:2gpv, PDBj:2gpv
PDBsum	2gpv
PubMed	16990259
UniProt	P62508\|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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