Structure of PDB 2gpu Chain A

Receptor sequence

>2gpuA (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]

YNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWA
KHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMD
EDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIE
DVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQ
HFYNIKLEGKVPMHKLFLEMLE

3D structure

PDB

2gpu X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Chain

Resolution

1.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	OHT	A	C269 A272 D273 E275 L309 Y326 F435 L440	C36 A39 D40 E42 L76 Y93 F202 L207	BindingDB: IC50=1350nM,EC50=15nM

External links

PDB	RCSB:2gpu, PDBe:2gpu, PDBj:2gpu
PDBsum	2gpu
PubMed	16990259
UniProt	P62508\|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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