Structure of PDB 2gpp Chain A

Receptor sequence

>2gppA (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]

PYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGW
AKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIM
DEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHI
EDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAV
QHFYNIKLEGKVPMHKLFLEMLEAK

3D structure

PDB

2gpp X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I280 K284 M298 E452	I48 K52 M66 E220
BS02	1BA	A	E247 I249 L268 A272 E275 L309 V313 R316 Y326 D328 F435	E15 I17 L36 A40 E43 L77 V81 R84 Y94 D96 F203	PDBbind-CN: -logKd/Ki=5.70,IC50=2.0uM

External links

PDB	RCSB:2gpp, PDBe:2gpp, PDBj:2gpp
PDBsum	2gpp
PubMed	16990259
UniProt	P62508\|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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