Structure of PDB 2gpo Chain A

Receptor sequence

>2gpoA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]

NKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAK
HIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE
DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIED
VEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQH
FYNIKLEGKVPMHKLFLEMLEAKV

3D structure

PDB

2gpo X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Chain

Resolution

1.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I280 K284 M298 L449 E452	I46 K50 M64 L215 E218

External links

PDB	RCSB:2gpo, PDBe:2gpo, PDBj:2gpo
PDBsum	2gpo
PubMed	16990259
UniProt	P62508\|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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