Structure of PDB 2gmj Chain A

Receptor sequence

>2gmjA (length=581) Species: 9823 (Sus scrofa) [Search protein sequence]

CKVPRITTHYTIYPRDQDKRWEGVNMERFAEEADVVIVGAGPAGLSAATR
LKQLAAQHEKDLRVCLVEKAAHIGAHTLSGACLDPRAFEELFPDWKEKGA
PLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYVVRLGHLVSWMGEQ
AEALGVEVYPGYAAAEILFHEDGSVKGIATNDVGIQKDGAPKTTFERGLE
LHAKVTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKKW
KPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLLALGFVVGLDYQNPYLSP
FREFQRWKHHPSIKPTLEGGKRIAYGARALNEGGFQSIPKLTFPGGLLIG
CSPGFMNVPKIKGTHTAMKSGTLAAESIFNQLTSENLQSKTIGLHVTEYE
DNLKNSWVWKELYSVRNIRPSCHGILGVYGGMIYTGIFYWIFRGMEPWTL
KHKGSDSDQLKPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAH
LTLKDDSVPVNRNLSIYDGPEQRFCPAGVYEFVPLEQGDGFRLQINAQNC
VHCKTCDIKDPSQNINWVVPEGGGGPAYNGM

3D structure

PDB

2gmj Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool.

Chain

Resolution

2.6 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	S82 R331 T367 C528 C553 C556 C559
Catalytic site (residue number reindexed from 1)	S79 R328 T364 C525 C550 C553 C556
Enzyme Commision number	1.5.5.1: electron-transferring-flavoprotein dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	A	L504 C528 P529 V532 C553 V554 C556 K557 T558 C559 W570	L501 C525 P526 V529 C550 V551 C553 K554 T555 C556 W567
BS02	FAD	A	G42 P45 A46 E71 K72 S82 G83 A84 C85 A167 A212 E213 G214 L333 C354 I364 K365 G366 T367	G39 P42 A43 E68 K69 S79 G80 A81 C82 A164 A209 E210 G211 L330 C351 I361 K362 G363 T364

Gene Ontology

	Molecular Function
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0048039	ubiquinone binding
GO:0050660	flavin adenine dinucleotide binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006979	response to oxidative stress
GO:0022900	electron transport chain
GO:0022904	respiratory electron transport chain

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2gmj, PDBe:2gmj, PDBj:2gmj
PDBsum	2gmj
PubMed	17050691
UniProt	P55931\|ETFD_PIG Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (Gene Name=ETFDH)

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